Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	732873
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	NR0B2
Name:	nuclear receptor subfamily 0 group B member 2

Acc ID:	CHEBI:77151
Term:	ginsenoside Rg2
Definition:	A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy group at position 6 has been converted to the corresponding alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.
Chemical ID:	MESH:C026474

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
NR0B2	increases activity	EXP		6480464	CTD	ginsenoside Rg2 results in increased activity of NR0B2 protein	PMID:22062806
NR0B2	increases expression	EXP		6480464	CTD	ginsenoside Rg2 results in increased expression of NR0B2 mRNA	PMID:22062806
NR0B2	multiple interactions	EXP		6480464	CTD	[[ginsenoside Rg2 results in increased phosphorylation of GSK3B protein] co-treated with [ginsenoside Rg2 results in increased expression of NR0B2 mRNA]] results in decreased chemical synthesis of Glucose; [ginsenoside Rg2 results in increased activity of NR0B2 protein] which results in decreased activity of CRTC2 protein	PMID:22062806

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