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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69106
Species: Mus musculus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:77149
Term: notoginsenoside R1
Definition: A ginsenoside found in Panax notoginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position.
Chemical ID: MESH:C072936
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2increases activityEXP 6480464CTDnotoginsenoside R1 results in increased activity of NR1I2 proteinPMID:25472953
Nr1i2increases response to substanceISONR1I2 (Homo sapiens)6480464CTDNR1I2 protein results in increased susceptibility to notoginsenoside R1PMID:25472953
Nr1i2multiple interactionsISONR1I2 (Homo sapiens)6480464CTDnotoginsenoside R1 binds to and results in increased activity of NR1I2 protein; NR1I2 protein promotes the reaction [notoginsenoside R1 results in increased expression of ABCB1 mRNA]; NR1I2 protein promotes the reaction [notoginsenoside R1 results in increased expression of UGT1A1 mRNA]PMID:25472953
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