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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346384
Species: Homo sapiens
RGD Object: Gene
Symbol: MPO
Name: myeloperoxidase
Acc ID: CHEBI:77149
Term: notoginsenoside R1
Definition: A ginsenoside found in Panax notoginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position.
Chemical ID: MESH:C072936
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MPOdecreases expressionISOMpo (Rattus norvegicus)6480464CTDnotoginsenoside R1 results in decreased expression of MPO proteinPMID:20023602
MPOmultiple interactionsISOMpo (Mus musculus)6480464CTDnotoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; notoginsenoside R1 inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]PMID:25472953
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