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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730823
Species: Homo sapiens
RGD Object: Gene
Symbol: ABCB1
Name: ATP binding cassette subfamily B member 1
Acc ID: CHEBI:77053
Term: closantel
Definition: A racemate comprising equimolar amounts of (R)- and (S)-clostanel. An anthelmintic, it is used (as the dihydrate of the sodium salt) in veterinary medicine for the treatment of fluke and nematode infections.
Chemical ID: MESH:C023342
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCB1decreases response to substanceISOAbcb1a (Mus musculus)6480464CTDABCB1A protein results in decreased susceptibility to closantelPMID:20513441
ABCB1multiple interactionsISOAbcb1a (Mus musculus)6480464CTDclosantel results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]PMID:20513441
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