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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736559
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR1
Name: estrogen receptor 1
Acc ID: CHEBI:77013
Term: beta-naphthoflavone
Definition: An extended flavonoid resulting from the formal fusion of a benzene ring with the f side of flavone.
Chemical ID: MESH:D019324
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR1affects bindingEXP 6480464CTD[beta-Naphthoflavone binds to AHR protein] which binds to ESR1 proteinPMID:10620335
ESR1decreases expressionISOEsr1 (Rattus norvegicus)6480464CTDbeta-Naphthoflavone results in decreased expression of ESR1 mRNAPMID:20607812
ESR1multiple interactionsISOEsr1 (Rattus norvegicus)6480464CTD[alpha-naphthoflavone co-treated with beta-Naphthoflavone] results in decreased expression of ESR1 mRNAPMID:22975028
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