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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731071
Species: Homo sapiens
RGD Object: Gene
Symbol: AHR
Name: aryl hydrocarbon receptor
Acc ID: CHEBI:77013
Term: beta-naphthoflavone
Definition: An extended flavonoid resulting from the formal fusion of a benzene ring with the f side of flavone.
Chemical ID: MESH:D019324
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AHRaffects bindingEXP 6480464CTD[beta-Naphthoflavone binds to AHR protein] which binds to ESR1 protein; [beta-Naphthoflavone binds to AHR protein] which binds to ESRRA protein; [beta-Naphthoflavone binds to AHR protein] which binds to NR2F1 protein; beta-Naphthoflavone binds to AHR proteinPMID:10620335 PMID:16705413
AHRaffects localizationEXP 6480464CTDbeta-Naphthoflavone affects the localization of AHR proteinPMID:11752201
AHRaffects response to substanceEXP 6480464CTDAHR protein affects the susceptibility to beta-NaphthoflavonePMID:22234961
AHRdecreases expressionEXP 6480464CTDbeta-Naphthoflavone results in decreased expression of AHR mRNA; beta-Naphthoflavone results in decreased expression of AHR proteinPMID:16985168 PMID:24161567 PMID:32151702
AHRincreases activityEXP 6480464CTDbeta-Naphthoflavone results in increased activity of AHR proteinPMID:16399344 PMID:19901195 PMID:22234961 PMID:23377616 PMID:23439660 PMID:26187274 PMID:26204831 PMID:26593447
AHRincreases expressionEXP 6480464CTDbeta-Naphthoflavone results in increased expression of AHR mRNAPMID:21262253
AHRmultiple interactionsEXP 6480464CTD[beta-Naphthoflavone binds to and results in increased activity of AHR protein] results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]; [beta-Naphthoflavone results in increased activity of AHR protein] which results in decreased chemical synthesis of and results in decreased secretion of Cholesterol; AHR gene mutant form inhibits the reaction [beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]]; AHR mutant form inhibits the reaction [beta-Naphthoflavone results in increased activity of [FASLG protein binds to FASLG protein]]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of CYP1A1 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of FDFT1 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of HMGCR mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of LSS mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of SQLE mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; beta-Naphthoflavone binds to and results in increased activity of AHR protein; beta-Naphthoflavone binds to and results in increased activity of AHR protein polymorphism; beta-Naphthoflavone binds to and results in increased activity of and results in increased localization of AHR protein; beta-Naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; beta-Naphthoflavone promotes the reaction [[AHR protein binds to UGT1A1 enhancer] which results in increased expression of UGT1A1 mRNA]; beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]; beta-Naphthoflavone promotes the reaction [AHR protein binds to GSTA1 promoter]; beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]; Carbaryl inhibits the reaction [beta-Naphthoflavone binds to and results in increased activity of AHR protein]; cryptotanshinone promotes the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA]; dihydrotanshinone I promotes the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA]; NR1I2 protein inhibits the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein inhibits the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA]]; tanshinone promotes the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA]PMID:12566446 PMID:12948865 PMID:15860653 PMID:17553063 PMID:19327395 PMID:19901195 PMID:20634293 PMID:21127131 PMID:21262253 PMID:22044530 PMID:22234961 PMID:22951985 PMID:24486526 PMID:28428138 PMID:29274324 PMID:31225620 PMID:33035518 PMID:9407059
AHRaffects bindingISOAhr (Mus musculus)6480464CTDbeta-Naphthoflavone binds to AHR proteinPMID:15297030 PMID:15371557
AHRaffects bindingISOAhr (Rattus norvegicus)6480464CTDbeta-Naphthoflavone binds to AHR proteinPMID:17431010
AHRaffects foldingISOAhr (Mus musculus)6480464CTDbeta-Naphthoflavone affects the folding of AHR proteinPMID:12527811
AHRaffects localizationISOAhr (Mus musculus)6480464CTDbeta-Naphthoflavone affects the localization of AHR proteinPMID:20106950 PMID:20634293
AHRaffects response to substanceISOAhr (Mus musculus)6480464CTDAHR gene alternative form affects the susceptibility to beta-Naphthoflavone; AHR protein affects the susceptibility to beta-NaphthoflavonePMID:22234961 PMID:29521512
AHRdecreases expressionISOAhr (Rattus norvegicus)6480464CTDbeta-Naphthoflavone results in decreased expression of AHR mRNAPMID:22975028
AHRincreases activityISOAhr (Mus musculus)6480464CTDbeta-Naphthoflavone results in increased activity of AHR proteinPMID:22491429 PMID:30203046
AHRincreases expressionISOAhr (Mus musculus)6480464CTDbeta-Naphthoflavone results in increased expression of AHR mRNAPMID:17627975 PMID:28428138
AHRmultiple interactionsISOAhr (Mus musculus)6480464CTD[beta-Naphthoflavone binds to AHR protein] which results in increased expression of ABCC2 mRNA; [beta-Naphthoflavone binds to AHR protein] which results in increased expression of ABCC3 mRNA; [beta-Naphthoflavone binds to AHR protein] which results in increased expression of ABCC5 mRNA; [beta-Naphthoflavone binds to AHR protein] which results in increased expression of ABCC6 mRNA; [beta-Naphthoflavone binds to and affects the localization of AHR protein] promotes the reaction [[AHR protein binds to CYP1A1 enhancer] which results in increased expression of CYP1A1 mRNA]; [beta-Naphthoflavone binds to and affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [furafylline results in decreased activity of CYP1A2 protein] promotes the reaction [beta-Naphthoflavone results in increased activity of AHR protein]; AHR affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; AHR affects the reaction [beta-Naphthoflavone results in increased expression of PPARA mRNA]; AHR affects the reaction [beta-Naphthoflavone results in increased expression of PPARA protein]; AHR gene alternative form affects the reaction [beta-Naphthoflavone results in decreased expression of CSN2 mRNA]; AHR gene alternative form affects the reaction [beta-Naphthoflavone results in decreased expression of LALBA mRNA]; AHR gene alternative form affects the reaction [beta-Naphthoflavone results in decreased expression of WAP mRNA]; AHR gene alternative form affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; AHR promotes the reaction [beta-Naphthoflavone results in decreased abundance of Lactic Acid]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of ACAT2 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of ADGRL2 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of CES2E mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of CES3 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of COQ10B mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of CYB5B mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of CYP51 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of DHCR7 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of DMGDH mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of FDFT1 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of FOS protein]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of GBP6 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of HAGH mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of HMGCR mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of HMGCS1 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of HSD17B7 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of IDI1 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of IRGM mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of LSS mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of MSMO1 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of MVD mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of NAT8F2 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of NSDHL mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of PCSK9 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of PMVK mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of RCAN2 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of RDH11 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of SERPINA7 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of SQLE mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of UGCG mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in increased expression of UBE2L3 mRNA]; AHR protein promotes the reaction [beta-Naphthoflavone results in increased activity of CRYZ protein]; beta-Naphthoflavone binds to and affects the localization of AHR protein; beta-Naphthoflavone binds to and results in increased activity of AHR protein; beta-Naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]; beta-Naphthoflavone promotes the reaction [AHR protein binds to BMAL1 protein]; beta-Naphthoflavone promotes the reaction [AHR protein binds to PER1 promoter]; beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]; kaempferol inhibits the reaction [beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]]PMID:12409613 PMID:15297030 PMID:15833929 PMID:15919853 PMID:17012224 PMID:18835618 PMID:20106950 PMID:20634293 PMID:21292640 PMID:21849270 PMID:22234961 PMID:22491429 PMID:25716673 PMID:26318284 PMID:29521512 PMID:3005314
AHRmultiple interactionsISOAhr (Rattus norvegicus)6480464CTDAHR protein promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone promotes the reaction [beta-Naphthoflavone results in decreased expression of AHR mRNA]; beta-Naphthoflavone binds to and results in increased activity of AHR protein; beta-Naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]PMID:11752103 PMID:20634293 PMID:22975028 PMID:3005314
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