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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736559
Species: Homo sapiens
RGD Object: Gene
Symbol: ESR1
Name: estrogen receptor 1
Acc ID: CHEBI:77012
Term: methylseleninic acid
Definition: An organoselenium compound that is seleninic acid in which the hydrogen attached to selenium is replaced by a methyl group.
Chemical ID: MESH:C008493
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESR1decreases expressionEXP 6480464CTDmethylselenic acid results in decreased expression of ESR1 mRNA; methylselenic acid results in decreased expression of ESR1 proteinPMID:15833885 PMID:16093440 PMID:16155795
ESR1multiple interactionsEXP 6480464CTD[methylselenic acid co-treated with afimoxifene] results in decreased expression of ESR1 mRNA; [methylselenic acid co-treated with afimoxifene] results in decreased expression of ESR1 protein; methylselenic acid inhibits the reaction [Estradiol binds to ESR1 protein]; methylselenic acid results in decreased expression of and results in decreased activity of ESR1 proteinPMID:15833885 PMID:16093440
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