GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | AKT1 | decreases phosphorylation | EXP | | 6480464 | CTD | methylselenic acid results in decreased phosphorylation of AKT1 protein | PMID:15845651 PMID:17339365 | AKT1 | decreases response to substance | EXP | | 6480464 | CTD | AKT1 protein results in decreased susceptibility to methylselenic acid | PMID:15845651 | AKT1 | multiple interactions | EXP | | 6480464 | CTD | [methylselenic acid results in decreased phosphorylation of AKT1 protein] which results in increased susceptibility to Doxorubicin; AKT1 protein modified form inhibits the reaction [[Doxorubicin co-treated with methylselenic acid] results in increased degradation of PARP1 protein]; methylselenic acid inhibits the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein] | PMID:17339365 | | ||||||||||||||||||||||
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