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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69147
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP9
Name: caspase 9
Acc ID: CHEBI:77012
Term: methylseleninic acid
Definition: An organoselenium compound that is seleninic acid in which the hydrogen attached to selenium is replaced by a methyl group.
Chemical ID: MESH:C008493
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP9increases cleavageEXP 6480464CTD[methylselenic acid results in increased cleavage of CASP9 protein] which results in increased cleavage of CASP8 protein; methylselenic acid results in increased cleavage of CASP9 proteinPMID:18444175 PMID:18790785
CASP9increases expressionEXP 6480464CTDmethylselenic acid results in increased expression of CASP9 mRNAPMID:12517777
CASP9multiple interactionsEXP 6480464CTD[2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid co-treated with methylselenic acid co-treated with resveratrol] results in increased cleavage of CASP9 protein; [[methylselenic acid co-treated with Tamoxifen] results in increased cleavage of CASP9 protein] which results in increased cleavage of CASP8 protein; [Doxorubicin co-treated with methylselenic acid] results in increased cleavage of and results in increased activity of CASP9 protein; [methylselenic acid co-treated with Tamoxifen] results in increased cleavage of CASP9 protein; BCL2L11 protein promotes the reaction [[Doxorubicin co-treated with methylselenic acid] results in increased cleavage of and results in increased activity of CASP9 protein]; methylselenic acid results in increased cleavage of and results in increased activity of CASP9 proteinPMID:17339365 PMID:18444175 PMID:18790785 PMID:28161410
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