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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:77012
Term: methylseleninic acid
Definition: An organoselenium compound that is seleninic acid in which the hydrogen attached to selenium is replaced by a methyl group.
Chemical ID: MESH:C008493
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8increases cleavageISOCASP8 (Homo sapiens)6480464CTD[methylselenic acid results in increased cleavage of CASP9 protein] which results in increased cleavage of CASP8 protein; methylselenic acid results in increased cleavage of CASP8 proteinPMID:18790785
Casp8multiple interactionsISOCASP8 (Homo sapiens)6480464CTD[2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid co-treated with methylselenic acid co-treated with resveratrol] results in increased cleavage of CASP8 protein; [[methylselenic acid co-treated with Tamoxifen] results in increased cleavage of CASP9 protein] which results in increased cleavage of CASP8 protein; [methylselenic acid co-treated with Tamoxifen] results in increased cleavage of CASP8 proteinPMID:18444175 PMID:18790785
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