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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69097
Species: Homo sapiens
RGD Object: Gene
Symbol: LHB
Name: luteinizing hormone subunit beta
Acc ID: CHEBI:77006
Term: 17beta-estradiol 3-benzoate
Definition: A benzoate ester resulting from the formal condensation of benzoic acid with the phenolic hydroxy group of 17beta-estradiol.
Chemical ID: MESH:C074283
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LHBdecreases expressionISOLhb (Mus musculus)6480464CTDestradiol 3-benzoate results in decreased expression of LHB mRNAPMID:15223135
LHBdecreases expressionISOLhb (Rattus norvegicus)6480464CTDestradiol 3-benzoate results in decreased expression of LHB mRNAPMID:16614383
LHBdecreases secretionISOLhb (Rattus norvegicus)6480464CTDestradiol 3-benzoate results in decreased secretion of LHB proteinPMID:16614383 PMID:24316378
LHBincreases secretionISOLhb (Rattus norvegicus)6480464CTDestradiol 3-benzoate results in increased secretion of LHB proteinPMID:10696778 PMID:17398000
LHBmultiple interactionsISOLhb (Mus musculus)6480464CTD[estradiol 3-benzoate co-treated with Progesterone] results in increased abundance of LHB proteinPMID:22577852
LHBmultiple interactionsISOLhb (Rattus norvegicus)6480464CTDAtrazine inhibits the reaction [[estradiol 3-benzoate co-treated with Progesterone] results in increased secretion of LHB protein]; Atrazine inhibits the reaction [estradiol 3-benzoate results in increased secretion of LHB protein]; Quercetin inhibits the reaction [estradiol 3-benzoate results in decreased secretion of LHB protein]; Raloxifene Hydrochloride inhibits the reaction [estradiol 3-benzoate results in increased secretion of LHB protein]PMID:10696778 PMID:15056801 PMID:17398000 PMID:24316378
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