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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1319403
Species: Homo sapiens
RGD Object: Gene
Symbol: FOXO3
Name: forkhead box O3
Acc ID: CHEBI:76995
Term: alpha-naphthoflavone
Definition: An extended flavonoid resulting from the formal fusion of a benzene ring with the h side of flavone. A synthetic compound, it is an inhibitor of aromatase (EC 1.14.14.14).
Chemical ID: MESH:C011512
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FOXO3multiple interactionsEXP 6480464CTDalpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of FOXO3 protein]PMID:22266097
FOXO3multiple interactionsISOFoxo3 (Rattus norvegicus)6480464CTD[Methylcholanthrene co-treated with alpha-naphthoflavone] results in increased expression of FOXO3 mRNAPMID:29094188
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