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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10289
Species: Mus musculus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:76995
Term: alpha-naphthoflavone
Definition: An extended flavonoid resulting from the formal fusion of a benzene ring with the h side of flavone. A synthetic compound, it is an inhibitor of aromatase (EC 1.14.14.14).
Chemical ID: MESH:C011512
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityEXP 6480464CTDalpha-naphthoflavone results in increased activity of CASP3 proteinPMID:18334599
Casp3increases cleavageEXP 6480464CTDalpha-naphthoflavone results in increased cleavage of CASP3 proteinPMID:30508555
Casp3multiple interactionsEXP 6480464CTDalpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased cleavage of CASP3 protein]PMID:35908932
Casp3decreases activityISOCasp3 (Rattus norvegicus)6480464CTDalpha-naphthoflavone results in decreased activity of CASP3 proteinPMID:15710172
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