GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PLCG2 | decreases phosphorylation | EXP | | 6480464 | CTD | ibrutinib results in decreased phosphorylation of PLCG2 protein | PMID:26254443 | PLCG2 | decreases response to substance | EXP | | 6480464 | CTD | PLCG2 protein mutant form results in decreased susceptibility to ibrutinib | PMID:27542411 | PLCG2 | multiple interactions | EXP | | 6480464 | CTD | (+)-JQ1 compound promotes the reaction [ibrutinib results in decreased phosphorylation of PLCG2 protein]; ibrutinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of PLCG2 protein] | PMID:26254443 | |
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