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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1323392
Species: Mus musculus
RGD Object: Gene
Symbol: Prdm1
Name: PR domain containing 1, with ZNF domain
Acc ID: CHEBI:76612
Term: ibrutinib
Definition: A member of the class of acrylamides that is (3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine in which the piperidine nitrogen is replaced by an acryloyl group. A selective and covalent inhibitor of the enzyme Bruton's tyrosine kinase, it is used for treatment of B-cell malignancies.
Chemical ID: MESH:C551803
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13233916480464CTDPCI 32765 results in decreased expression of PRDM1 mRNA

PMID:26254443
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.