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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11476
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase 1 family, polypeptide A1
Acc ID: CHEBI:76604
Term: MeIQx
Definition: An imidazoquinoxaline that is 3H-imidazo[4,5-f]quinoxaline substituted at positions 3 and 8 by methyl groups and at position 2 by an amino group. A mutagenic compound found in cooked beef.
Chemical ID: MESH:C036990
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13500186480464CTD2-amino-3, 8-dimethylimidazo(4, 5-f)quinoxaline results in increased expression of UGT1A1 mRNA

PMID:22138251, PMID:23810796
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.