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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550475
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp27a1
Name: cytochrome P450, family 27, subfamily a, polypeptide 1
Acc ID: CHEBI:76591
Term: (25R)-cholest-5-ene-3beta,26-diol
Definition: A 26-hydroxycholesterol in which the 25-position has R-configuration.
Chemical ID: MESH:C076996
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp27a1increases abundanceISOCYP27A1 (Homo sapiens)6480464CTDCYP27A1 protein results in increased abundance of 27-hydroxycholesterolPMID:12119285
Cyp27a1increases chemical synthesisISOCYP27A1 (Homo sapiens)6480464CTDCYP27A1 protein results in increased chemical synthesis of 27-hydroxycholesterolPMID:11714861 PMID:12531903 PMID:14622972
Cyp27a1multiple interactionsISOCYP27A1 (Homo sapiens)6480464CTD[[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein; [CYP27A1 protein results in increased hydroxylation of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol; [CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol; [CYP27A1 protein results in increased oxidation of 27-hydroxycholesterol] which results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid; [TGFB1 protein results in increased expression of CYP27A1 protein] which results in increased abundance of 27-hydroxycholesterolPMID:11408283 PMID:15708352 PMID:9215552 PMID:9660774
Cyp27a1multiple interactionsISOCyp27a1 (Rattus norvegicus)6480464CTD[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterolPMID:8496670
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