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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732740
Species: Homo sapiens
RGD Object: Gene
Symbol: CAT
Name: catalase
Acc ID: CHEBI:76451
Term: alloxan
Definition: A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.
Chemical ID: MESH:D000496
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CATdecreases activityISOCat (Rattus norvegicus)6480464CTDAlloxan results in decreased activity of CAT proteinPMID:10871429 PMID:19693677 PMID:21982801
CATdecreases activityISOCat (Mus musculus)6480464CTDAlloxan results in decreased activity of CAT proteinPMID:24946265 PMID:28419827
CATdecreases expressionISOCat (Rattus norvegicus)6480464CTDAlloxan results in decreased expression of CAT proteinPMID:19393637
CATmultiple interactionsISOCat (Rattus norvegicus)6480464CTD3,4-dihydroxyphenylethanol inhibits the reaction [Alloxan results in decreased expression of CAT protein]; Chromium inhibits the reaction [Alloxan results in decreased activity of CAT protein]; chromium tripicolinate inhibits the reaction [Alloxan results in decreased activity of CAT protein]; D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in decreased activity of CAT protein]; Plant Extracts inhibits the reaction [Alloxan results in decreased expression of CAT protein]PMID:19393637 PMID:19693677 PMID:21982801
CATmultiple interactionsISOCat (Mus musculus)6480464CTDPlant Oils inhibits the reaction [Alloxan results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Alloxan results in decreased activity of CAT protein]PMID:24946265 PMID:28419827
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