Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10816
Species: Mus musculus
RGD Object: Gene
Symbol: Irs1
Name: insulin receptor substrate 1
Acc ID: CHEBI:76451
Term: alloxan
Definition: A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.
Chemical ID: MESH:D000496
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Irs1affects phosphorylationEXP 6480464CTDAlloxan affects the phosphorylation of IRS1 proteinPMID:26827782
Irs1multiple interactionsEXP 6480464CTDPhycocyanin inhibits the reaction [Alloxan affects the phosphorylation of IRS1 protein]PMID:26827782
Irs1decreases phosphorylationISOIrs1 (Rattus norvegicus)6480464CTDAlloxan results in decreased phosphorylation of IRS1 proteinPMID:22138235
Irs1multiple interactionsISOIrs1 (Rattus norvegicus)6480464CTDTaurine inhibits the reaction [Alloxan results in decreased phosphorylation of IRS1 protein]PMID:22138235
Go Back to source page   Continue to Ontology report