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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:76359
Term: butylated hydroxyanisole
Definition: A mixture of 2-tert-butyl-4-hydroxyanisole and 3-tert-butyl-4-hydroxyanisole. Is is used as an antioxidant and preservative in food, cosmetics, pharmaceuticals, rubber and petroleum products.
Chemical ID: MESH:D002083
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDButylated Hydroxyanisole results in increased expression of NQO1 mRNA

PMID:18227147
multiple interactionsEXP 6480464CTDButylated Hydroxyanisole promotes the reaction [FOS protein binds to NQO1 promoter], Butylated Hydroxyanisole promotes the reaction [JUN protein binds to NQO1 promoter]

PMID:8375015
increases activityISORGD:104736480464CTDButylated Hydroxyanisole results in increased activity of NQO1 protein

PMID:10092053
increases activityISORGD:25036480464CTDButylated Hydroxyanisole results in increased activity of NQO1 protein

PMID:16045903
increases expressionISORGD:104736480464CTDButylated Hydroxyanisole results in increased expression of NQO1 mRNA, Butylated Hydroxyanisole results in increased expression of NQO1 protein

PMID:11309284, PMID:15919853, PMID:16403784, PMID:17627975, PMID:19144771, PMID:25922074, PMID:29086419
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.