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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:76359
Term: butylated hydroxyanisole
Definition: A mixture of 2-tert-butyl-4-hydroxyanisole and 3-tert-butyl-4-hydroxyanisole. Is is used as an antioxidant and preservative in food, cosmetics, pharmaceuticals, rubber and petroleum products.
Chemical ID: MESH:D002083
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:107176480464CTDButylated Hydroxyanisole results in increased expression of HMOX1 mRNA

PMID:25922074
increases expressionISORGD:7309016480464CTDButylated Hydroxyanisole results in increased expression of HMOX1 mRNA

PMID:18227147
multiple interactionsISORGD:7309016480464CTD1-aminobenzotriazole inhibits the reaction [[Butylated Hydroxyanisole co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA], [Hydrogen Peroxide co-treated with Butylated Hydroxyanisole] results in increased expression of HMOX1 mRNA, Buthionine Sulfoximine promotes the reaction [Butylated Hydroxyanisole results in increased expression of HMOX1 mRNA]

PMID:18227147, PMID:29486183
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.