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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2543
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Egfr
Name: epidermal growth factor receptor
Acc ID: CHEBI:76237
Term: (20R)-protopanaxadiol
Definition: A diastereomer of protopanaxadiol in which the 20-hydroxy substituent has been introduced at the pro-R position.
Chemical ID: MESH:C062916
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egfrdecreases activityISOEGFR (Homo sapiens)6480464CTDprotopanaxadiol results in decreased activity of EGFR proteinPMID:31805304
Egfrmultiple interactionsISOEGFR (Homo sapiens)6480464CTDprotopanaxadiol results in decreased expression of and results in increased phosphorylation of EGFR proteinPMID:31805304
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