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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313391
Species: Homo sapiens
RGD Object: Gene
Symbol: IDH2
Name: isocitrate dehydrogenase (NADP(+)) 2
Acc ID: CHEBI:76208
Term: sodium sulfide (anhydrous)
Definition: A sulfide salt with formula Na2S. The pentahydrate and (particularly) the nonahydrate are also known. In gel form, sodium sulfide is used to soften toenails to assist in trimming (and so relive pain) of ingrowing toenails.
Chemical ID: MESH:C033479
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IDH2multiple interactionsISOIdh2 (Rattus norvegicus)6480464CTD[[sodium sulfide results in increased abundance of Hydrogen Sulfide] which co-treated with Paraquat] results in decreased expression of IDH2 protein; [sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in decreased expression of and results in decreased activity of IDH2 protein]PMID:32064027
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