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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1558284
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt1a2
Name: UDP glucuronosyltransferase 1 family, polypeptide A2
Acc ID: CHEBI:76162
Term: indoprofen
Definition: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(1-oxo-1,3-dihydroisoindol-2-yl)phenyl group. Initially used as an anti-inflammatory and analgesic, it was withdrawn from the market due to causing severe gastrointestinal bleeding. It has been subsequently found to increase production of the survival motor neuron protein.
Chemical ID: MESH:D007216
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a2increases glucuronidationISOUGT1A3 (Homo sapiens)6480464CTDUGT1A3 protein results in increased glucuronidation of IndoprofenPMID:15117964
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