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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311159
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Alox12
Name: arachidonate 12-lipoxygenase, 12S type
Acc ID: CHEBI:76114
Term: benoxaprofen
Definition: A monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group. It was used as a non-steroidal anti-inflammatory drug until 1982 when it was withdrawn from the market due to adverse side-effects including liver necrosis, photosensitivity, and carcinogenicity in animals.
Chemical ID: MESH:C011677
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alox12decreases activityEXP 6480464CTDbenoxaprofen results in decreased activity of ALOX12 proteinPMID:3928952
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