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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620250
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh1a2
Name: aldehyde dehydrogenase 1 family, member A2
Acc ID: CHEBI:76010
Term: dolutegravir
Definition: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (4R,12aS)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid with the amino group of 2,4-difluorobenzylamine. Used (as its sodium salt) for treatment of HIV-1.
Chemical ID: MESH:C562325
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh1a2decreases expressionISOAldh1a2 (Mus musculus)6480464CTDdolutegravir results in decreased expression of ALDH1A2 mRNAPMID:34515794
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