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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:76004
Term: dimethyl fumarate
Definition: An enoate ester resulting from the formal condensation of both carboxy groups of fumaric acid with methanol. Used for treatment of adults with relapsing forms of multiple sclerosis.
Chemical ID: MESH:C056020
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngmultiple interactionsISOIFNG (Homo sapiens)6480464CTDDimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CD74 mRNA]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CIITA mRNA]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CXCL10 mRNA]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CXCL9 mRNA]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of HLA-DRA mRNA]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of IRF1 mRNA]; Dimethyl Fumarate inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]PMID:15663561 PMID:30021835
Ifngmultiple interactionsISOIfng (Mus musculus)6480464CTDDimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; tin protoporphyrin IX inhibits the reaction [Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]PMID:23942037
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