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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350980
Species: Homo sapiens
RGD Object: Gene
Symbol: MT-CO3
Name: mitochondrially encoded cytochrome c oxidase III
Acc ID: CHEBI:76004
Term: dimethyl fumarate
Definition: An enoate ester resulting from the formal condensation of both carboxy groups of fumaric acid with methanol. Used for treatment of adults with relapsing forms of multiple sclerosis.
Chemical ID: MESH:C056020
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MT-CO3increases expressionISOmt-Co3 (Mus musculus)6480464CTDDimethyl Fumarate results in increased expression of COX3 mRNAPMID:27277809
MT-CO3multiple interactionsISOmt-Co3 (Mus musculus)6480464CTDNFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of COX3 mRNA]PMID:27277809
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