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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308152
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Creb3l3
Name: cAMP responsive element binding protein 3-like 3
Acc ID: CHEBI:75998
Term: trametinib
Definition: A pyridopyrimidine that is used (as its dimethyl sulfoxide addition compound) for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment.
Chemical ID: MESH:C560077
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Creb3l3multiple interactionsISOCREB3L3 (Homo sapiens)6480464CTD[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CREB3L3 mRNAPMID:36139627
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