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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733282
Species: Mus musculus
RGD Object: Gene
Symbol: Slc22a4
Name: solute carrier family 22 (organic cation transporter), member 4
Acc ID: CHEBI:75984
Term: flecainide
Definition: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid with the primary amino group of piperidin-2-ylmethylamine. An antiarrhythmic agent used (in the form of its acetate salt) to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart).
Chemical ID: MESH:D005424
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a4multiple interactionsISOSLC22A4 (Homo sapiens)6480464CTDFlecainide inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]PMID:21641380
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