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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730935
Species: Homo sapiens
RGD Object: Gene
Symbol: HIF1A
Name: hypoxia inducible factor 1 subunit alpha
Acc ID: CHEBI:7596
Term: nitroprusside
Definition: An iron coordination entity that has formula C5FeN6O.
Chemical ID: MESH:D009599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HIF1Adecreases activityEXP 6480464CTDNitroprusside results in decreased activity of HIF1A proteinPMID:15465035
HIF1Adecreases expressionEXP 6480464CTDNitroprusside results in decreased expression of HIF1A mRNA; Nitroprusside results in decreased expression of HIF1A proteinPMID:15465035
HIF1Amultiple interactionsEXP 6480464CTDNitroprusside inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; Nitroprusside inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]PMID:11286986 PMID:28624453
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