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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:7596
Term: nitroprusside
Definition: An iron coordination entity that has formula C5FeN6O.
Chemical ID: MESH:D009599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDNitroprusside results in decreased expression of BCL2 proteinPMID:10203697
Bcl2multiple interactionsEXP 6480464CTDFGF2 protein inhibits the reaction [Nitroprusside results in decreased expression of BCL2 protein]; IGF1 protein inhibits the reaction [Nitroprusside results in decreased expression of BCL2 protein]PMID:10203697
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDNitroprusside results in decreased expression of BCL2; Nitroprusside results in decreased expression of BCL2 proteinPMID:15708893 PMID:23665936
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[Nitroprusside results in increased nitrosation of and results in decreased ubiquitination of and results in decreased degradation of BCL2 protein] which results in decreased susceptibility to ChromatesPMID:16980304
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