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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68997
Species: Homo sapiens
RGD Object: Gene
Symbol: IGF1R
Name: insulin like growth factor 1 receptor
Acc ID: CHEBI:7590
Term: nitrofen
Definition: An organic molecular entity that has formula C12H7Cl2NO3.
Chemical ID: MESH:C007350
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IGF1Rdecreases expressionISOIgf1r (Rattus norvegicus)6480464CTDnitrofen results in decreased expression of IGF1R mRNA; nitrofen results in decreased expression of IGF1R proteinPMID:20620343 PMID:21433279
IGF1Rmultiple interactionsISOIgf1r (Rattus norvegicus)6480464CTDTretinoin inhibits the reaction [nitrofen results in decreased expression of IGF1R mRNA]; Tretinoin inhibits the reaction [nitrofen results in decreased expression of IGF1R protein]PMID:21433279
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