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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730855
Species: Homo sapiens
RGD Object: Gene
Symbol: SOD1
Name: superoxide dismutase 1
Acc ID: CHEBI:75725
Term: (R,R)-tramadol
Definition: A 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol in which both stereocentres have R-configuration; the (R,R)-enantiomer of the racemic opioid analgesic tramadol, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer.
Chemical ID: MESH:D014147
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOD1decreases expressionISOSod1 (Rattus norvegicus)6480464CTDTramadol results in decreased expression of SOD1 mRNA; Tramadol results in decreased expression of SOD1 proteinPMID:25550769 PMID:31618080
SOD1multiple interactionsISOSod1 (Rattus norvegicus)6480464CTDTramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA]PMID:25550769
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