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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:75725
Term: (R,R)-tramadol
Definition: A 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol in which both stereocentres have R-configuration; the (R,R)-enantiomer of the racemic opioid analgesic tramadol, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer.
Chemical ID: MESH:D014147
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2d4affects metabolic processingISORGD:7362176480464CTDCYP2D6 gene mutant form affects the metabolism of Tramadol, CYP2D6 gene polymorphism affects the metabolism of Tramadol

PMID:12191703, PMID:17570739, PMID:18520597
Cyp2d4affects methylationISORGD:7362186480464CTDCYP2D6 protein affects the methylation of Tramadol

PMID:12893130
Cyp2d4affects response to substanceISORGD:7362176480464CTDCYP2D6 gene polymorphism affects the susceptibility to Tramadol, CYP2D6 protein affects the susceptibility to Tramadol

PMID:16497087, PMID:16960721
Cyp2d4decreases methylationISORGD:7362176480464CTDCYP2D6 protein results in decreased methylation of Tramadol

PMID:14624403, PMID:17361124, PMID:17470523
Cyp2d4decreases response to substanceISORGD:7362176480464CTDCYP2D6 gene polymorphism results in decreased susceptibility to Tramadol

PMID:16960721
Cyp2d4increases metabolic processingISORGD:7362176480464CTDCYP2D6 gene mutant form results in increased metabolism of Tramadol, CYP2D6 protein results in increased metabolism of Tramadol

PMID:18204346, PMID:18520597, PMID:18713907, PMID:29555325
Cyp2d4increases response to substanceISORGD:7362176480464CTDCYP2D6 gene mutant form results in increased susceptibility to Tramadol

PMID:18204346
Cyp2d4multiple interactionsISORGD:7362176480464CTD[CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol, CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol, CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol

PMID:18204346, PMID:29555325
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.