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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1593276
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pdk3
Name: pyruvate dehydrogenase kinase 3
Acc ID: CHEBI:75725
Term: (R,R)-tramadol
Definition: A 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol in which both stereocentres have R-configuration; the (R,R)-enantiomer of the racemic opioid analgesic tramadol, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer.
Chemical ID: MESH:D014147
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdk3increases expressionISORGD:13431636480464CTDTramadol results in increased expression of PDK3 mRNAPMID:27317026
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