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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 12185421
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: ACHE
Name: acetylcholinesterase
Acc ID: CHEBI:75701
Term: sarin
Definition: A racemate composed of equal amounts of (R)- and (S)-sarin. A potent and irreversible inhibitor of acetylcholinesterase that is toxic to the nervous system and is employed as a chemical warfare agent.
Chemical ID: MESH:D012524
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACHEdecreases activityEXP 6480464CTDSarin results in decreased activity of ACHE proteinPMID:16915560
ACHEmultiple interactionsEXP 6480464CTD[Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]PMID:16915560
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