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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2460
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:7565
Term: nifedipine
Definition: A dihydropyridine that has formula C17H18N2O6.
Chemical ID: MESH:D009543
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1b1decreases activityISOCyp1b1 (Mus musculus)6480464CTDNifedipine results in decreased activity of CYP1B1 proteinPMID:18420780
Cyp1b1decreases activityISOCYP1B1 (Homo sapiens)6480464CTDNifedipine results in decreased activity of CYP1B1 proteinPMID:33814510
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