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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732092
Species: Mus musculus
RGD Object: Gene
Symbol: Fzd2
Name: frizzled class receptor 2
Acc ID: CHEBI:7553
Term: niclosamide
Definition: A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.
Chemical ID: MESH:D009534
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fzd2decreases expressionISOFZD2 (Homo sapiens)6480464CTDNiclosamide results in decreased expression of FZD2 mRNAPMID:22576131
Fzd2increases expressionISOFZD2 (Homo sapiens)6480464CTDNiclosamide results in increased expression of FZD2 mRNAPMID:36318118
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