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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69147
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP9
Name: caspase 9
Acc ID: CHEBI:7553
Term: niclosamide
Definition: A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.
Chemical ID: MESH:D009534
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP9increases cleavageEXP 6480464CTDNiclosamide results in increased cleavage of CASP9 proteinPMID:26703449 PMID:30258081
CASP9increases expressionEXP 6480464CTDNiclosamide results in increased expression of CASP9 mRNA; Niclosamide results in increased expression of CASP9 protein modified formPMID:26116531 PMID:36318118
CASP9multiple interactionsEXP 6480464CTDTP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP9 protein]PMID:30258081
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