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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69005
Species: Mus musculus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:7553
Term: niclosamide
Definition: A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.
Chemical ID: MESH:D009534
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3multiple interactionsEXP 6480464CTDNiclosamide affects the reaction [FAS protein mutant form affects the phosphorylation of STAT3 protein]PMID:33632240
Stat3decreases expressionISOSTAT3 (Homo sapiens)6480464CTDNiclosamide analog results in decreased expression of STAT3 protein; Niclosamide results in decreased expression of STAT3 proteinPMID:26116531 PMID:28284560
Stat3decreases phosphorylationISOSTAT3 (Homo sapiens)6480464CTDNiclosamide analog results in decreased phosphorylation of STAT3 protein; Niclosamide results in decreased phosphorylation of STAT3 proteinPMID:23333246 PMID:23894143 PMID:28284560 PMID:29031202 PMID:29251334 PMID:30329025
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTD[Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; enzalutamide promotes the reaction [Niclosamide results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; Niclosamide inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein]; Niclosamide inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; Niclosamide inhibits the reaction [STAT3 protein results in decreased susceptibility to enzalutamide]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of STAT3 protein]; Niclosamide results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of STAT3 protein; Niclosamide results in decreased expression of and results in decreased phosphorylation of STAT3 proteinPMID:23894143 PMID:24552774 PMID:25970160 PMID:26792726 PMID:30779072
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