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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313354
Species: Homo sapiens
RGD Object: Gene
Symbol: NKX3-1
Name: NK3 homeobox 1
Acc ID: CHEBI:7553
Term: niclosamide
Definition: A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.
Chemical ID: MESH:D009534
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NKX3-1decreases expressionEXP 6480464CTDNiclosamide results in decreased expression of NKX3-1 mRNAPMID:28500234
NKX3-1multiple interactionsEXP 6480464CTD[Niclosamide co-treated with bicalutamide] results in decreased expression of NKX3-1 mRNAPMID:28500234
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