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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346665
Species: Homo sapiens
RGD Object: Gene
Symbol: TNFRSF10B
Name: TNF receptor superfamily member 10b
Acc ID: CHEBI:75408
Term: sulindac sulfide
Definition: An aryl sulfide that is a metabolite of sulindac. A non-steroidal anti-inflammatory drug, which also has anticancer activity.
Chemical ID: MESH:C025462
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFRSF10Bincreases expressionEXP 6480464CTDsulindac sulfide results in increased expression of TNFRSF10B mRNA; sulindac sulfide results in increased expression of TNFRSF10B proteinPMID:11559570 PMID:12203115 PMID:15180942
TNFRSF10Bmultiple interactionsEXP 6480464CTDsulindac sulfide inhibits the reaction [PTGS2 protein results in decreased expression of TNFRSF10B mRNA]PMID:12208739
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