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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2149
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Areg
Name: amphiregulin
Acc ID: CHEBI:75404
Term: tyrphostin AG 1478
Definition: A member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist.
Chemical ID: MESH:C101044
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aregdecreases activityISOAreg (Mus musculus)6480464CTDRTKI cpd results in decreased activity of AREG proteinPMID:15706222
Aregmultiple interactionsISOAREG (Homo sapiens)6480464CTDRTKI cpd inhibits the reaction [[AREG protein co-treated with Estradiol] results in increased phosphorylation of EGFR protein]PMID:21185374
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