Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2520
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Drd2
Name: dopamine receptor D2
Acc ID: CHEBI:75401
Term: quinpirole
Definition: A pyrazoloquinoline that is (4aR,8aR)-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrazolo[3,4-g]quinoline substituted by a propyl group at position 5. It acts as a dopamine agonist.
Chemical ID: MESH:D019257
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Drd2affects response to substanceEXP 6480464CTDDRD2 protein affects the susceptibility to QuinpirolePMID:12071432
Drd2multiple interactionsEXP 6480464CTD[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine; cypermethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; decamethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]; estradiol 3-benzoate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; Haloperidol inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; Mirtazapine inhibits the reaction [Quinpirole binds to DRD2 protein]; Nifedipine inhibits the reaction [DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]]; Quinpirole binds to and results in increased activity of DRD2 protein; tautomycin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]PMID:10936494 PMID:11124974 PMID:12523492 PMID:1724532
Drd2increases activityISODRD2 (Homo sapiens)6480464CTDQuinpirole results in increased activity of DRD2 proteinPMID:27920206
Drd2increases response to substanceISODrd2 (Mus musculus)6480464CTDDRD2 results in increased susceptibility to QuinpirolePMID:11790512
Drd2increases response to substanceISODRD2 (Homo sapiens)6480464CTDDRD2 protein results in increased susceptibility to QuinpirolePMID:27920206
Drd2multiple interactionsISODrd2 (Mus musculus)6480464CTDDRD2 affects the susceptibility to [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole]; DRD2 protein affects the reaction [Quinpirole results in increased phosphorylation of CFL1 protein]PMID:27717053 PMID:9547254
Drd2multiple interactionsISODRD2 (Homo sapiens)6480464CTD[Quinpirole binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium; [Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Quinpirole co-treated with DRD2 protein alternative form] results in increased activity of RHOA protein; DRD2 protein promotes the reaction [Quinpirole results in decreased expression of POU5F1 mRNA]; epigallocatechin gallate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; JB-788 inhibits the reaction [Quinpirole binds to and results in increased activity of DRD2 protein]; Quinpirole binds to and results in increased activity of DRD2 protein; Sulpiride inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]PMID:17958328 PMID:20580787 PMID:27717053 PMID:27920206 PMID:8032591
Go Back to source page   Continue to Ontology report