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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621351
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col1a2
Name: collagen type I alpha 2 chain
Acc ID: CHEBI:75393
Term: Y-27632
Definition: A monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It has been shown to exhibit inhibitory activity against Rho-associated protein kinase (ROCK) enzyme.
Chemical ID: MESH:C108830
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7309846480464CTDY 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL1A2 mRNA], Y 27632 inhibits the reaction [Oxygen results in increased expression of COL1A2 mRNA]

PMID:21439370, PMID:23517783, PMID:30682444
multiple interactionsISORGD:7309856480464CTDY 27632 inhibits the reaction [Oxygen results in increased expression of COL1A2 mRNA]

PMID:21439370
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.