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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61817
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col1a1
Name: collagen type I alpha 1 chain
Acc ID: CHEBI:75393
Term: Y-27632
Definition: A monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It has been shown to exhibit inhibitory activity against Rho-associated protein kinase (ROCK) enzyme.
Chemical ID: MESH:C108830
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col1a1multiple interactionsISOCol1a1 (Mus musculus)6480464CTDY 27632 inhibits the reaction [Oxygen results in increased expression of COL1A1 mRNA]PMID:21439370
Col1a1multiple interactionsISOCOL1A1 (Homo sapiens)6480464CTDY 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of COL1A1 mRNA]; Y 27632 inhibits the reaction [Oxygen results in increased expression of COL1A1 mRNA]PMID:21439370 PMID:23517783 PMID:30682444
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