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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1616012
Species: Mus musculus
RGD Object: Gene
Symbol: Acta2
Name: actin alpha 2, smooth muscle, aorta
Acc ID: CHEBI:75393
Term: Y-27632
Definition: A monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It has been shown to exhibit inhibitory activity against Rho-associated protein kinase (ROCK) enzyme.
Chemical ID: MESH:C108830
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acta2multiple interactionsEXP 6480464CTDY 27632 inhibits the reaction [Oxygen results in increased expression of ACTA2 protein]; Y 27632 inhibits the reaction [Soot results in increased expression of ACTA2 mRNA]; Y 27632 inhibits the reaction [Soot results in increased expression of ACTA2 protein]PMID:23517783 PMID:33792148
Acta2decreases expressionISOActa2 (Rattus norvegicus)6480464CTDY 27632 results in decreased expression of ACTA2 mRNAPMID:11035001
Acta2multiple interactionsISOACTA2 (Homo sapiens)6480464CTDY 27632 inhibits the reaction [Oxygen results in increased expression of ACTA2 mRNA]; Y 27632 inhibits the reaction [Oxygen results in increased expression of ACTA2 protein]PMID:23517783
Acta2multiple interactionsISOActa2 (Rattus norvegicus)6480464CTDY 27632 affects the reaction [Dibutyl Phthalate affects the expression of ACTA2 mRNA]; Y 27632 affects the reaction [Dibutyl Phthalate affects the expression of ACTA2 protein]; Y 27632 inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Y 27632 inhibits the reaction [Dibutyl Phthalate results in increased expression of ACTA2 mRNA]; Y 27632 inhibits the reaction [Dibutyl Phthalate results in increased expression of ACTA2 protein]PMID:13678700 PMID:32860865
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