RGD ID: 620410
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ltb4r
Name: leukotriene B4 receptor
Acc ID: CHEBI:75390
Term: 3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid
Definition: A member of the class of indoles that is 1H-indole substituted by a isopropyl group at position 5, a tert-butylsulfanediyl group at position 3, a 4-chlorobenzyl group at position 1 and a 2-carboxy-2-methylpropyl group at position 2. It acts as an inhibitor of arachidonate 5-lipoxygenase.
Chemical ID: MESH:C060893
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDMK-886 binds to and results in decreased activity of LTB4R protein

MK-886 inhibits the reaction [LTB4R protein results in increased susceptibility to Formaldehyde]

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.