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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734299
Species: Homo sapiens
RGD Object: Gene
Symbol: BCL2L11
Name: BCL2 like 11
Acc ID: CHEBI:75270
Term: nimustine
Definition: An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-amino-2-methylpyrimidin-5-ylmethyl] group. An antineoplastic agent especially effective against malignant brain tumors.
Chemical ID: MESH:D015376
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BCL2L11increases expressionEXP 6480464CTDNimustine results in increased expression of BCL2L11 mRNA; Nimustine results in increased expression of BCL2L11 proteinPMID:26418950
BCL2L11multiple interactionsEXP 6480464CTDBCL2L11 mutant form inhibits the reaction [Nimustine results in increased cleavage of CASP9 protein]; pyrazolanthrone inhibits the reaction [Nimustine results in increased expression of BCL2L11 mRNA]PMID:26418950
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